Rose, the 2013 US Open Champion, started the day tied for the lead with home favourite Marc Warren, but left all his rivals trailing in his wake with a flawless display that featured five birdies on the front nine and one more on the back to reach 16 under par for the week. It was his second victory in succession, following his triumph at Congressional on the US PGA Tour last month.
"It's the first time I've won in Scotland as a pro and I'm delighted to have won on The European Tour again," said Rose. "I was pretty calm because I had a good start and built up a bit of a lead. On the 15th I holed a slippery five-footer to stay three ahead, but on 16 I was wide of the green in a really bad spot, and I saw on the leaderboard that my lead was down to two. That was the moment I was really tested, but I made the best up-and-down I've made all week, and to keep myself two ahead was very, very important.
"On Wednesday there was no way I was winning this tournament. I think I lost about seven balls in the pro-am. Sometimes it takes a few rounds to get into your rhythm, and I really think having a scorecard in my hand this week really helped my preparation and really helped my game get better.
"I could have been on the range for four days and probably not got to the level with my game that I'm at now because of playing a tournament. Playing under a little bit of pressure and making adjustments in terms of hitting numbers really helps. I'm very excited for next week."
Warren eventually signed for a one under par 70, good enough for third place, three shots behind runner-up Kristoffer Broberg of Sweden, who closed with a 66. Another Scot, Stephen Gallacher, equalled the course record with a 63 for a share of fourth place, alongside England's Tyrrell Hatton (68), Irishman Shane Lowry (66) and Italy's Matteo Manassero (65).
Broberg, Hatton and Scotland's Scott Jamieson, who was tied eighth thanks to an eight under par 64, claimed the three spots up for grabs for next week's Open Championship.
Rose will move to number three in the world as a result of his victory and despite an ordinary Open Championship record will now come into calculations as a genuine chance to add the Open Championship to the US Open he won in 2013.
Other encouraging efforts in terms of the Open Championship came from Rickie Fowler (8th) with a last round of 65, Phil Mickelson (11th) also with a final round of 65, Rory McIlroy (14th) and Luke Donald (16th).
The best of the Australians was Wade Ormsby who finished 51st.