Pilkadaris is still chasing his first PGA Tour of Australasia after nearly 16 years of trying although he has won on the Asian Tour on three occasions.
Kim Felton, Matthew Stieger and Jun Sok Lee are tied in third position just two shots from the lead.
Former winner, Scott Arnold, is amongst a group of four people at 1 under and three from the lead.
Only nine players finished the opening 36 holes under par following a brutal opening day yesterday.
Pilkadaris, who played the European Challenge Tour last season and has been one of the great journeymen of Australian golf in recent years, was first off at 7.30 in round two at the Creek Course and added a second round of 70 but for former NSW Amateur Champion Drewitt, who turned professional last August, his was a different story.
Drewitt began his round at the 10th and after his opening round of 75 he needed something special. The Sydney based Inverell golfer recorded two good finishes in Tier 2 events in the West but was unable to secure his status for 2014 and was required to attend Tour School where he finished 34th but had done enough to earn start this week.
Drewitt began with an eagle and two birdies in his first four holes today and finished strongly also.
First round leader Aaron Townsend slipped to a share of 14th with a second round of 76.
The leading amateur is South Australian Anthony Murdaca
The cut fell at 4 over with 57 players making it through to the weekend.
The Oates Victorian Open for men is being played in conjunction with the Oates Women's Victorian Open which is led by Queenslander and LPGA Tour player, Sarah Jane Smith.
Smith led by four after yesterday's opening round but added a 71 today to be three ahead of the in form West Australian Amateur Minjee Lee. Lee has been runner-up and 11th against considerably stronger fields over the past two weeks and appears a great chance to challenge Smith.
Canberra's Nikki Campbell produced the only round in the 60's today when she recorded a brilliant 67 to recover from her horror opening round of 79. Campbell shares 3rd position with American Hannah Jun while defending champion Stacey Keating kept her hopes of back to back wins alive.
Keating is at even par and seven from the lead but alone in 5th position alone.