Reed held off spirited challenges from Ryan Palmer (2nd) Zach Johnson and Justin Leonard (tie 3rd) and Brian Stuard (5th), the round of 62 by Johnson continuing his brilliant recent form.
Reed led throughout, recording consecutive rounds of 63 over the opening three rounds at the La Quinta Country Club, Nicklaus Course at PGA West and the Palmer Private layout at PGA West to lead by seven heading into day four.
It proved to be a roller coaster for the leader over the first twelve holes of the final round as his nerves and the chasing pack combined to apply the upmost pressure.
A birdie at the 15th from 25 feet proved crucial as it opened the gap to three and allowed him to steady the ship over the closing three holes.
It wasn't pretty but it was effective and for the man whose regular caddie and wife, Justine, is off the bag at present as the pair await the arrival of their first child, the US$1,008,000 will help relive the anxiety of a tense final day.
Stuart Appleby produced his best finish since his 9th place at the Travelers Championship last year and only his second top ten in more than three years when he finished in a share of 9th. Appleby birdied seven of his last 13 holes for a round of 65 and what will be a welcome cheque for close to US125,000.
Matt Jones had another solid week when he finished tied for 13th but he will be disappointed with a final round which included a double bogey at his 9th hole.
Steve Bowditch was 48th and John Senden 69th.
The PGA Tour now moves back to the coast and to San Diego for the Farmers Insurance Open at Torrey Pines.