Wilson emerged from a final round dogfight to claim the Humana Challenge in Partnership with the Clinton Foundation in La Quinta in California, winning by two over John Mallinger, last week's winner Johnson Wagner and Robert Garrigus.
Jeff Maggert finished alone in 5th position with Australia's John Senden continuing his good record in this event by finishing in a share of 6th position with David Toms.
Wilson, who started the final round three ahead, recovered from a slow start to birdie four of his last eight holes at the Palmer Course at PGA West, including one at the last to edge ahead of a long list of potential winners.
Wilson holed a very important bunker shot at the 12th to take the lead and held on as his challengers came and went over the closing stages.
Garrigus was tied with Wilson with two to play but a bogey at the par three 17th and the birdie by Wilson at last resulted in the two shot difference.
Senden played this event well earlier in his career and when he moved to 4 under for the day and 19 under for the tournament with a birdie at the 11th it appeared he was still a winning chance.
At the 13th however Senden found the water with his approach and although able to save bogey his chance of winning was all but gone. Senden though would birdie two of his last three holes to finish in the share of 6th and has made a solid start to the season.
Jarrod Lyle, back on the PGA Tour after regaining his card at the recent Tour School, finished as the next best Australasian after Senden in 26th place while Danny Lee and Nick O'Hern were 26th.
Lee, now playing the PGA Tour as a card holder, produced one of the highlights of the day when he holed in one at the par three 17th which was the 8th hole of his round.
The PGA Tour will now move south to San Diego and Torrey Pines for this week's Farmer Insurance Open.